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  • Pagoclone
  • Pagoclone
  • Pagoclone

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Pagoclone

Pagoclone

Basic Information

CAS No.: 133737-48-1
Molecular Formula: C23H22ClN3O2
Molecular weight: 407.89

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product description

Pagolone is a specific GABA (Gamma-aminobutyric acid) receptor modulator that can reduce stuttering. Pagolone is a novel cyclopyrrolone that acts as a partial GABA (A) receptor agonist.


Chemical Properties

PropertyValue

Boiling point

582.1±50.0 °C(Predicted)

density

1.273±0.06 g/cm3(Predicted)

pka

1.62±0.30(Predicted)

InChI

InChI=1S/ C23H22ClN3O2/ c1-14(2) 7-10-16(28) 13-19-17-5-3-4-6-18(17) 23(29) 27(19)21-12-9-15-8-11-20 (24) 25-22(15) 26-21/ h3-6,8-9,11-12, 14, 19H, 7,10, 13H2, 1-2H3

InChIKey

HIUPRQPBWVEQJJ-UHFFFAOYSA-N

SMILES

C1(=O)C2= C(C=CC=C2)C(CC(=O)CCC(C)C)N1C1= CC=C2C(=N1)N=C(Cl)C=C2


Product Usage

Pagoclone is a non-benzodiazepine anxiolytic compound belonging to the cyclopyrrolone family. As a selective GABA-A receptor partial agonist, its primary pharmaceutical application has been the focus of clinical research for treating generalized anxiety disorder (GAD) and panic disorders. Unlike traditional benzodiazepines, pagoclone is designed to provide anti-anxiety effects with significantly reduced sedative and amnestic side effects. Furthermore, it has gained international attention for its potential application in treating persistent developmental stuttering, with clinical trials exploring its ability to improve speech fluency. In the research sector, it serves as a critical reference standard for studying receptor subtype selectivity and the development of next-generation social ligands.

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FAQ

Q1: What international standards do your products and services comply with?

A1: Our products fully comply with international standards such as REACH, MSDS, and COA, and we strictly implement the ISO9001 quality management system. We can also provide third-party testing reports (SGS, BV, etc.) according to customer needs.


Q2: How long does it take for goods to be delivered to my country?
A2: The delivery time depends on the transport mode and destination country. Generally, sea transport takes 15-30 days, air transport takes 3-7 days, and we will optimize the transport route to shorten the delivery time as much as possible.


Can you provide customs clearance services for dangerous chemicals?
A3: Yes. Our team is proficient in the customs clearance procedures for dangerous chemicals in various countries, and can provide professional compliant declaration and customs clearance services to ensure smooth customs clearance.


Q4: Do you provide customized product and service solutions?
A4: Yes. We can provide personalized product customization and export service solutions according to your specific needs (product specifications, application scenarios, procurement volume, etc.).

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